We sequence cells to understand how genetic mutations form and change cell states in health and disease.

The Computational Neurology group develops theory- and data-based methods with the goal of achieving a more comprehensive understanding of neurological system function. In addition to the general goal of a more quantitative neurology, this approach should contribute to a more objective, real-time monitoring with continuous risk assessment and,…

The Integrative Vascular Biology Laboratory aims to unravel the fundamental principles and molecular/genetic regulation of functional vascular network formation in development and disease.

The Medical Omics lab aims to improve healthcare and basic research by providing artificial intelligence-driven tools for the analysis of large biomedical datasets. For comprehensive insights in disease entities, we aim to include multiple layers of data, such as single-cell RNA sequencing, methylomics data and medical imaging. In close…

Rapid advances in molecular biology technologies are leading to a data explosion in biomedical research and clinical diagnostics. The goal of our department is to develop new and targeted ways to analyze and evaluate these data sets in order to implement innovations that benefit patients. For instance, it is desirable to make information from…

Content will follow shortly

During the Corona pandemic, half a million researchers from more than 170 different fields published articles about the virus or the COVID-19 disease. Many of them were not really virus-experts, even automobile researchers published about Corona. In the new episode of the BIH-podcast, John Ioannidis, famous meta-researcher from Stanford and Berlin,…

Not only the DNA sequence – our genome – but also the 3D structure of our genome – the 'epi-genome' – is essential in determining the type and function of a cell. That's why the analysis of the epigenome facilitates deep insights into the developmental history of a cell and its current gene expression profile, but also allows deductions on its…

The main research area of the Bioinformatics and Translational Genetics group is the elucidation of single gene disorders (diseases caused by DNA mutations in a single gene). We are developing user-friendly software that can be used by non-IT specialists. This allows the physicians – who know most about the patients and their disorders – to analyse…